REVIEW ARTICLE


Neglected Respiratory Toxicity Caused by Cancer Therapy Alternate Title: The Importance of the Infrequent Respiratory Side-Effects of Cancer Treatment



Christian Domingo*, 1, Jorge Roig2
1 Servei de Pneumologia. Hospital de Sabadell (Corporació Parc Taulí)- Departament of Medicine, Universitat Autònoma de Barcelona (UAB) Sabadell (Barcelona/Spain). Anatomy and Physiology Department, Facultat de Ciències de la Salut, Universitat Internacional de Catalunya (UIC). Barcelona, Spain
2 Unitat de Pneumologia. Hospital Nostra Senyora de Meritxell. Escaldes-Engordany, Principality of Andorra


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ꀉ 2007 Bentham Science Publishers Ltd.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.

* Address correspondence to this author at the Servei de Pneumologia, Hospital de Sabadell (Corporació Parc Taulí), Departament de Medicina, Uni-versitat Autònoma de Barcerlona (UAB), Corporació Parc Taulí, Parc Taulí s/n, 08208 Sabadell, Barcelona, Spain; Tel: 34-93 723 10 10, Ext. 21 160; Fax: 34-93 716 06 46; E-mail: cdomingo@cspt.es


Abstract

When a patient with lung cancer presents non-specific respiratory symptoms there are many diagnostic options. Chemotherapy is the cornerstone of treatment in many stages of lung cancer and its toxicity is well known. The main priority is to prevent life-threatening diseases such as lung infection, which can be treated successfully if a prompt, accurate diagnosis is given. Drug-induced pulmonary disease must be avoided at all costs but it is also important to avoid side-effects of drugs which do not directly interfere with respiratory physiology but may impair gas exchange. This review highlights the risks and characteristics of non-cytostatic-induced lung toxicity caused by agents that have been commonly used to treat cancer in recent decades. Physicians should be alert to the possibility of this neglected non-chemotherapy-induced lung toxicity in cancer patients, since early withdrawal of the offending drug is mandatory.

Keywords: Non-chemotherapy-induced lung toxicity, administration route toxicity, lung injury, cancer treatment toxicity.