The Emerging Role of The Eosinophil and Its Measurement in Chronic Cough



Mahboobeh H. Sadeghi, Alyn H. Morice*
Respiratory Medicine, Castle Hill Hospital, Centre for Cardiovascular and Metabolic Research, Hull York Medical School, Cottingham, UK.


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© 2017 Sadeghi & Morice

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Head of Cardiorespiratory Studies, Hull York Medical School, Castle Hill Hospital, Cottingham, HU16 5JQ, UK.Tel:+441482624067; Fax:+215-3109757; E-mail: A.H.Morice@hull.ac.uk


Abstract

Although the aetiology of chronic cough in guidelines is clearly stated as asthma and related syndromes, gastro-oesophageal reflux disease (GORD), and upper airways disease, the inflammatory mechanisms underlying these conditions differ. Recent studies on asthma have increasingly focused on its molecular phenotypes instead of clinical characteristics. Here, we proposed the hypothesis that divides cough into two groups; the eosinophilic and neutrophilic. This division will enhance our ability to recognise the type of airway inflammation which, as a consequence will lead us to more targeted and personalized treatment approaches.

Keywords: Chronic Cough, Eosinophil, Cough variant asthma, Eosinophilic bronchitis, Montelukast, Innate immunity.