Quantification of Mouse Lung Elastin During Prenatal Development

Rodrigues, Paula; Gonçalves, Carlos; Honório, Ana; Barros, José; Bairos, Vasco

Quantification of Mouse Lung Elastin During Prenatal Development

Paula Rodrigues¹, Carlos Gonçalves^{*, 2}, Ana Honório³, José Barros⁴, Vasco Bairos⁵

¹ Department of Pathology and Veterinary Clinics – University of Trás-os-Montes e Alto Douro, (UTAD) Vila Real, Portugal; Center for Animal and Veterinary Sciences, UTAD, Vila Real, Portugal

² Institute of Histology and Embryology, Faculty of Medicine of Coimbra, Portugal; Center for Histophysiology, Experimental Pathology and Developmental Biology, Faculty of Medicine of Coimbra, Portugal; Service of Neonatology, Hospital of the University of Coimbra, Portugal

³ Institute of Histology and Embryology, Faculty of Medicine of Coimbra, Portugal

⁴ Center for Histophysiology, Experimental Pathology and Developmental, Biology, Faculty of Medicine of Coimbra, Portugal; Service of Obstetrics, Hospital of the University of Coimbra, Portugal

⁵ Institute of Histology and Embryology, Faculty of Medicine of Coimbra, Portugal; Center for Histophysiology, Experimental Pathology and Developmental Biology, Faculty of Medicine of Coimbra, Portugal

Article Information

Identifiers and Pagination:

Year: 2008
Volume: 2
First Page: 46
Last Page: 51
Publisher ID: TORMJ-2-46
DOI: 10.2174/1874306400802010046

Article History:

Received Date: 6/3/2008
Revision Received Date: 17/4/2008
Acceptance Date: 1/5/2008
Electronic publication date: 15/5/2008
Collection year: 2008

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© Rodrigues et al.; Licensee Bentham Open.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/license/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.

^* Address correspondence to this author at the Institute of Histology and Embryology, Faculty of Medicine of Coimbra, 3004-504, Coimbra, Portugal; E-mail: carlos.condeixa@gmail.com;carloscond55@hotmail.com

Elastic fibres play a crucial function during the process of lung alveolisation. During the perinatal period, any changes in the elastogenic process during foetal development may result in permanent lifetime defects. In pre-natal life, well-developed pulmonary elastic fibres should favor the pre-natal maturation of the lung and an enhanced alveolisation, which in many species, such as humans begins only after birth. The authors present a quantitative study by image analysis and by high-pressure liquid chromatography (HPLC) of the mouse lungs’ elastic fibre content from the 15th till the 19th gestational day.

Keywords: Lung development, elastic fibres, elastin, desmosin..

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RESEARCH ARTICLE

Quantification of Mouse Lung Elastin During Prenatal Development

Article Information

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Abstract

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