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Marked Improvement in Pulmonary Arterial Hypertension in 3 Patients with a History of Amphetamine-like Drug use and Comorbidities
The Open Respiratory Medicine Journal
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17 Apr 2026 •
CASE REPORT
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DOI: 10.2174/0118743064473701260415041740
Abstract
Introduction/background
The prognosis of patients with Pulmonary Hypertension (PAH) associated with the intake of anorexigens and amphetamines has not been clearly defined. Published data are suboptimal due to a scarcity of corroborating hemodynamic information. There are reports of worse, the same, and better prognoses compared to patients with idiopathic pulmonary arterial hypertension.
Case presentation
Our experience with three patients who had PAH, a history of amphetamine-like drug use, and comorbidities is described, and the pertinent literature is summarized.
Conclusion
Three patients with PAH and a history of amphetamine-like drug use demonstrated markedly improved hemodynamics at follow-up catheterizations.
Keywords: Pulmonary hypertension, Amphetamine-like drugs, Catheterization, Case report.