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Effectiveness of Rituximab in Severe Wegener’s Granulomatosis: Report of Two Cases and Review of the Literature
Joaquim Oristrell, *
Guillermina Bejarano
Rosa Jordana
Manuel Monteagudo
Begoña Marí
Arnau Casanovas
Carles Tolosa
Authors Info & Affiliations
Guillermina Bejarano
Rosa Jordana
Manuel Monteagudo
Begoña Marí
Arnau Casanovas
Carles Tolosa
Authors Info & Affiliations
The Open Respiratory Medicine Journal
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25 June 2009 •
RESEARCH ARTICLE
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DOI: 10.2174/1874306400903010094
Abstract
We hereby describe the satisfactory evolution of rituximab treatment in two patients with Wegener’s granulomatosis (WG). Rituximab was indicated for refractoriness to standard treatment in one case and life-threatening myelotoxicity due to alkylating agents in the other. A brief review of previous experience with the use of rituximab in the treatment of WG is presented.
Keywords: Rituximab, Wegener’s granulomatosis, rescue treatment..