RESEARCH ARTICLE


Effectiveness of Rituximab in Severe Wegener’s Granulomatosis: Report of Two Cases and Review of the Literature



Joaquim Oristrell*, Guillermina Bejarano, Rosa Jordana, Manuel Monteagudo, Begoña Marí, Arnau Casanovas, Carles Tolosa
Internal Medicine Service, Hospital de Sabadell, Corporació Parc Taulí, Universitat Autònoma de Barcelona (UAB), Spain


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© Oristrell et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Corporació Parc Taulí, Parc Tauli s/n, 08208 Sabadell, Barcelona, Spain; Tel: + 34-937 458 252; Fax: 34-937 160 646; E-mail: joristrell@tauli.cat


Abstract

We hereby describe the satisfactory evolution of rituximab treatment in two patients with Wegener’s granulomatosis (WG). Rituximab was indicated for refractoriness to standard treatment in one case and life-threatening myelotoxicity due to alkylating agents in the other. A brief review of previous experience with the use of rituximab in the treatment of WG is presented.

Keywords: Rituximab, Wegener’s granulomatosis, rescue treatment..