Effectiveness of Rituximab in Severe Wegener’s Granulomatosis: Report of Two Cases and Review of the Literature

Oristrell, Joaquim; Bejarano, Guillermina; Jordana, Rosa; Monteagudo, Manuel; Marí, Begoña; Casanovas, Arnau; Tolosa, Carles

Effectiveness of Rituximab in Severe Wegener’s Granulomatosis: Report of Two Cases and Review of the Literature

Joaquim Oristrell^*, Guillermina Bejarano, Rosa Jordana, Manuel Monteagudo, Begoña Marí, Arnau Casanovas, Carles Tolosa

Internal Medicine Service, Hospital de Sabadell, Corporació Parc Taulí, Universitat Autònoma de Barcelona (UAB), Spain

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Identifiers and Pagination:

Year: 2009
Volume: 3
First Page: 94
Last Page: 99
Publisher ID: TORMJ-3-94
DOI: 10.2174/1874306400903010094

Article History:

Received Date: 31/3/2009
Revision Received Date: 14/4/2009
Acceptance Date: 22/5/2009
Electronic publication date: 25/6/2009
Collection year: 2009

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© Oristrell et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

^* Address correspondence to this author at the Corporació Parc Taulí, Parc Tauli s/n, 08208 Sabadell, Barcelona, Spain; Tel: + 34-937 458 252; Fax: 34-937 160 646; E-mail: joristrell@tauli.cat

We hereby describe the satisfactory evolution of rituximab treatment in two patients with Wegener’s granulomatosis (WG). Rituximab was indicated for refractoriness to standard treatment in one case and life-threatening myelotoxicity due to alkylating agents in the other. A brief review of previous experience with the use of rituximab in the treatment of WG is presented.

Keywords: Rituximab, Wegener’s granulomatosis, rescue treatment..

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RESEARCH ARTICLE

Effectiveness of Rituximab in Severe Wegener’s Granulomatosis: Report of Two Cases and Review of the Literature

Article Information

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Abstract

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About the Journal

The Open Respiratory Medicine Journal

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