RESEARCH ARTICLE

Reduction of Raf Kinase Inhibitor Protein Expression is Associated with Lymph Node Metastasis in Resectable Non-small Cell Lung Cancer

Huang Yan1 Lin Guoqiang2 Chen Shengxi2 Deng Zhenghao3 Huang Lingjin, * Open Modal , 2 Authors Info & Affiliations
The Open Respiratory Medicine Journal • 30 Nov 2012 • RESEARCH ARTICLE • DOI: 10.2174/1874306401206010135

Abstract

Introduction:

Raf kinase inhibitor protein (RKIP) had been identified as one of prognostic indictor in various malignant diseases. Association of RKIP expression and the clinical-pathological features were not investigated in patients with resectable non-small cell lung cancer (NSCLC).

Materials and Methodology:

159 sectioned samples from surgical NSCLC patients were investigated by immunohistochemistry in order to reveal the associations between RKIP expression and clinical-pathologic features.

Results:

Statistically, Lower RKIP expression level was found in the group with higher N stage (P<0.01) and higher TNM stage (P<0.05). No significant correlation was observed between RKIP expressions and histologic type (P>0.05) and tumor size (P>0.05).

Conclusions:

Down expression level of RKIP was found relating to lymph node metastasis in resectable NSCLC patients in this study.

Keywords: : Raf kinase inhibitor protein, non-small cell lung cancer, lymph node metastasis..
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