RESEARCH ARTICLE


Reduction of Raf Kinase Inhibitor Protein Expression is Associated with Lymph Node Metastasis in Resectable Non-small Cell Lung Cancer



Huang Yan1, Lin Guoqiang2, Chen Shengxi2, Deng Zhenghao3, Huang Lingjin*, 2
1 Department of Infectious Disease, Xiangya Hospital, Central South University, Xiangya Road, Changsha, China
2 Department of Cardiothoracic Sugery, Xiangya Hospital, Central South University, Xiangya Road, Changsha, China
3 Department of Pathology, Xiangya Hospital, Central South University, Xiangya Road, Changsha, China


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© Yan et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Cardiothoracic Sugery, Xiangya Hospital, Central South University, Xiangya Road, Changsha, China; Tel: +8673184323003; E-mail: drhuanglj@gmail.com


Abstract

Introduction:

Raf kinase inhibitor protein (RKIP) had been identified as one of prognostic indictor in various malignant diseases. Association of RKIP expression and the clinical-pathological features were not investigated in patients with resectable non-small cell lung cancer (NSCLC).

Materials and Methodology:

159 sectioned samples from surgical NSCLC patients were investigated by immunohistochemistry in order to reveal the associations between RKIP expression and clinical-pathologic features.

Results:

Statistically, Lower RKIP expression level was found in the group with higher N stage (P<0.01) and higher TNM stage (P<0.05). No significant correlation was observed between RKIP expressions and histologic type (P>0.05) and tumor size (P>0.05).

Conclusions:

Down expression level of RKIP was found relating to lymph node metastasis in resectable NSCLC patients in this study.

Keywords: : Raf kinase inhibitor protein, non-small cell lung cancer, lymph node metastasis..