RESEARCH ARTICLE
Reduction of Raf Kinase Inhibitor Protein Expression is Associated with Lymph Node Metastasis in Resectable Non-small Cell Lung Cancer
Huang Yan1, Lin Guoqiang2, Chen Shengxi2, Deng Zhenghao3, Huang Lingjin*, 2
Article Information
Identifiers and Pagination:
Year: 2012Volume: 6
First Page: 135
Last Page: 138
Publisher ID: TORMJ-6-135
DOI: 10.2174/1874306401206010135
Article History:
Received Date: 3/8/2012Revision Received Date: 9/11/2012
Acceptance Date: 14/11/2012
Electronic publication date: 30/11/2012
Collection year: 2012

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
Abstract
Introduction:
Raf kinase inhibitor protein (RKIP) had been identified as one of prognostic indictor in various malignant diseases. Association of RKIP expression and the clinical-pathological features were not investigated in patients with resectable non-small cell lung cancer (NSCLC).
Materials and Methodology:
159 sectioned samples from surgical NSCLC patients were investigated by immunohistochemistry in order to reveal the associations between RKIP expression and clinical-pathologic features.
Results:
Statistically, Lower RKIP expression level was found in the group with higher N stage (P<0.01) and higher TNM stage (P<0.05). No significant correlation was observed between RKIP expressions and histologic type (P>0.05) and tumor size (P>0.05).
Conclusions:
Down expression level of RKIP was found relating to lymph node metastasis in resectable NSCLC patients in this study.