Reduction of Raf Kinase Inhibitor Protein Expression is Associated with Lymph Node Metastasis in Resectable Non-small Cell Lung Cancer
Huang Yan1, Lin Guoqiang2, Chen Shengxi2, Deng Zhenghao3, Huang Lingjin*, 2
Identifiers and Pagination:Year: 2012
First Page: 135
Last Page: 138
Publisher Id: TORMJ-6-135
Article History:Received Date: 3/8/2012
Revision Received Date: 9/11/2012
Acceptance Date: 14/11/2012
Electronic publication date: 30/11/2012
Collection year: 2012
open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
Raf kinase inhibitor protein (RKIP) had been identified as one of prognostic indictor in various malignant diseases. Association of RKIP expression and the clinical-pathological features were not investigated in patients with resectable non-small cell lung cancer (NSCLC).
Materials and Methodology:
159 sectioned samples from surgical NSCLC patients were investigated by immunohistochemistry in order to reveal the associations between RKIP expression and clinical-pathologic features.
Statistically, Lower RKIP expression level was found in the group with higher N stage (P<0.01) and higher TNM stage (P<0.05). No significant correlation was observed between RKIP expressions and histologic type (P>0.05) and tumor size (P>0.05).
Down expression level of RKIP was found relating to lymph node metastasis in resectable NSCLC patients in this study.