Association between Hypomagnesemia, COVID-19, Respiratory Tract and Lung Disease

Gavino Faa1, 2, Luca Saba3, Daniela Fanni1, 2, Goce Kalcev4, *, Mauro Carta5
1 Division of Pathology, Department of Medical Sciences and Public Health, University Hospital San Giovanni di Dio, Cagliari, Italy
2 Department of Biology, College of Science and Technology, Temple University, Philadelphia, PA, USA
3 Department of Medical Imaging, Azienda Ospedaliero Universitaria (AOU) of Cagliari-Polo di Monserrato, Cagliari, Italy
4 International Ph.D. in Innovation Sciences and Technologies, University of Cagliari, Cagliari, Italy
5 Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy

© 2021 Faa et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at International PhD in Innovation Sciences and Technologies, University of Cagliari, Italy, Via Ospedale, 46, 09124 Cagliari CA, Italy; E-mail: gocekalcev@yahoo.com


The complexity of COVID-19 is also related to the multiple molecular pathways triggered by SARS-CoV-2, which is able to cause type I pneumocyte death, trigger intravascular coagulation, interfere with the renin-angiotensin system, dysregulate iron metabolism, ending with the insurgence of a cytokine storm which may lead to death. Old adults with obesity, hypertension, and diabetes are among the high-risk category groups more prone to SARS-CoV-2 infection. Magnesium has been reported to play a major role both in physiology and in pathology, particularly in elderly people, regulating cytotoxic functions of natural killer (NK) cells and CD8+ T lymphocytes. In spite of the absence of controlled trials, the possibility of magnesium supplementation for supportive treatment in patients with COVID-19 should be encouraged. This could be useful in all phases of the COVID-19 disease.

Keywords: COVID-19, Magnesium, Effects, Magnesium deficiency, Lung diseases, Obesity.