Does Prior Training Affect Acute O2 Supply Responses During Exercise in Desaturator COPD Patients?

Delample Delphine *, 1, 2, Meritxell Sabate2, Christian Préfaut1, Fabienne Durand1, 2
1 INSERM ERI25 «Muscle and Pathologies», F-34295 Montpellier, France. Université Montpellier I, EA4202, F-34295 Montpellier, France
2 Laboratoire SSA “Sport Santé Altitude”, Département STAPS, Font-Romeu, France

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2008 Bentham Science Publishers Ltd

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.

* Address correspondence to this author at the INSERM ERI25, “Muscle and Pathologies », CHU A. de Villeneuve, 371 Avenue du Doyen Giraud, 34295 Montpellier, France; Tel: +33 467 335 910; Fax: +33 467 335 923; E-mail:



This study investigated the effects of a prior individualized training program (TP) on the response to acute oxygen supply during exercise in chronic obstructive pulmonary disease (COPD) patients showing exercise-induced desaturation.


Twenty-two COPD patients (mean [SD] FEV1 = 52.1 [3]% predicted) who desaturated on exercise participated in a TP. Exercise tolerance while breathing compressed air or oxygen was assessed using a walking test (WT) before and after TP. Oxygen flow was individualized.


Before TP, acute oxygen supply improved mean exercise tolerance. But this response was heterogeneous as only 8 patients increased their walking distance with oxygen. TP improved exercise tolerance in the entire population. However, a greater affect of oxygen administration during exercise was not observed after TP. The response to oxygen again showed great disparity as only 6 patients increased their walking distance with oxygen after TP.


The response to oxygen supply during exercise varied among COPD patients. Moreover, despite the clinical benefits of TP, no cumulative effect of TP and oxygen supply was observed during exercise performance.

Keywords: COPD, training program, oxygen, exercise..