Extra-Esophageal Manifestations of Gastroesophageal Reflux Disease: Controversies Between Epidemiology and Clicnic

Saber, Hamid; Ghanei, Mostafa

Extra-Esophageal Manifestations of Gastroesophageal Reflux Disease: Controversies Between Epidemiology and Clicnic

Hamid Saber¹, Mostafa Ghanei^{*, 2}

¹ Faculty of medicine, Mashhad University of Medical Sciences, Mashhad, Iran

² Research Center of Chemical Injuries, Baqiyatallah University of Medical Sciences, Tehran, Iran

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Identifiers and Pagination:

Year: 2012
Volume: 6
First Page: 121
Last Page: 126
Publisher ID: TORMJ-6-121
DOI: 10.2174/1874306401206010121

Article History:

Received Date: 20/9/2012
Revision Received Date: 4/10/2012
Acceptance Date: 4/10/2012
Electronic publication date: 2/11/2012
Collection year: 2012

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© Saber and Ghanei; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

^* Address correspondence to this author at the Baqiyatallah University of Medical, Sciences, Research Center of Chemical Injuries, P.O. Box: 19945-546, Tehran, Iran; Tel: +98 21 88600067; Fax: +98 21 88211524; E-mail: mghanei@hbi.ir

Gastroesophageal reflux disease (GERD) is widely associated with asthma, chronic cough, and laryngitis. Many studies have focused on acidic reflux; however, acid is just one of many factors that can cause pulmonary injury. The discrepancy between the high frequency of GERD in asthmatic patients and the ineffective reflux therapy outcomes in these patients suggests that GERD may cause injury through other mechanisms, such as pepsinogen, pepsin, bile salts, or other components of reflux materials, instead of the acid. Research using appropriate and innovative methodologies to investigate these potential inflammatory agents in patients with GERD is required to determine the underlying factors associated with pulmonary disorders in these patients.

Keywords: : Gastroesophageal reflux disease, respiratory, asthma, cough, epidemiology..

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RESEARCH ARTICLE

Extra-Esophageal Manifestations of Gastroesophageal Reflux Disease: Controversies Between Epidemiology and Clicnic

Article Information

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Article History:

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Abstract

Track Your Manuscript

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About the Journal

The Open Respiratory Medicine Journal

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Unique Views/Downloads: 129,921

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