Angiosarcoma Presenting with Spontaneous Hydropneumothorax: Report of a Case and Review of the Literature

Jung H Chang*, 1, Ji H Kim 1, So-Hyeon Hong 1, Myung E Song 1, Yon J Ryu 1, Jin H Lee 1, Sung S Shim 2, Min-Sun Cho 3, Yun S Sim 4
1 Division of Pulmonary and Critical Care Medicine, Department of Medicine
2 Department of Radiology
3 Pathology, School of Medicine, Ewha Womans University, Seoul, South Korea
4 Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Seoul, South Korea

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© Chang et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Division of Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine, Ewha Womans University, Anyangcheon-Ro 1071, Yangcheon-gu, Seoul, 158-710, South Korea; Tel : +82-2-2650-5686; Fax: +82-2-2655-2076; E-mail:


Angiosarcoma is a rare malignant tumor of soft tissue. Because angiosarcoma originates from endothelial cells, it can occur in any organ and shows aggressive clinical features. Most commonly, angiosarcoma initially presents as a cutaneous lesion. Lung metastasis from scalp angiosarcoma can develop pneumothorax. We report a case of multiorgan involvement of an angiosarcoma, including the scalp, initially presenting with hydropneumothorax. Immunohistochemistry analysis of the cells obtained from the study confirmed the pleural invasion of the angiosarcoma.

Keywords: Angiosarcoma, hydropneumothorax, immunohistochemistry, scalp..