Association of Interleukin-4 Receptor α Chain I50V Gene Variant (rs1805010) and Asthma in Iranian Population: A Case-control Study

Masouma Mowahedi1, Azam Aramesh2, Mozhgan Sorkhi Khouzani3, Marjan Sorkhi Khouzani3, Saeed Daryanoush2, Mohammad Samet4, Morteza Samadi5, *
1 Abortion Research Center, Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2 Thalassemia and Hemophilia Research Center, Shahid Dastgheib Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
3 Cellular and Molecular Biology - Genetic Center, Falavarjan Azad University, Isfahan, Iran
4 Shahid Sadoughi University of Medical Sciences, Yazd, Iran
5 Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Article Metrics

CrossRef Citations:
Total Statistics:

Full-Text HTML Views: 152
Abstract HTML Views: 100
PDF Downloads: 50
ePub Downloads: 41
Total Views/Downloads: 343
Unique Statistics:

Full-Text HTML Views: 84
Abstract HTML Views: 80
PDF Downloads: 45
ePub Downloads: 35
Total Views/Downloads: 244

Creative Commons License
© 2024 The Author(s). Published by Bentham Open.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to these authors at the Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran; Tel/Fax: 00983538367502; E-mail:



Asthma is one of the respiratory disorders caused by chronic airway inflammation. IL-4 has been identified as one of the participating interleukins in the severity of asthma.


A case-control study was conducted to determine the association of rs1805010, a single nucleotide polymorphism in the interleukin 4 receptor α chain, with asthma and immunoglobulin E and IL-17A serum levels in Iranian populations.


ELISA was used to investigate the relationship between three different varieties of SNP I50V and serum IL-17A levels, as well as total IgE levels. Based on GINA criteria, patients were classified into mild, moderate, and severe groups based on the association between SNP I50V, IL-17A, and total IgE. In order to analyze the data, the student-t-test and the one-way ANOVA were used.


The SNP I50V was associated with asthma in a significant way (p = 0.001). IL-17A and total IgE levels were significantly higher in asthmatic patients than in control participants (p 0.05 and p 0.021, respectively), but neither showed any association with SNP I50V in the asthmatic patients.


Asthma patients have a higher prevalence of the I allele, reflecting the significance of Th2 cells. Although total IgE and IL-17A levels increased in both disease subgroups, total IgE level augmentation correlates directly with disease severity, while IL-17A level enhancement does not.

Keywords: Asthma, I50V, IL-17A, IgE, Elisa, Respiratory disorders, Chronic airway inflammation.