Metabolic Alkalosis in Adults with Stable Cystic Fibrosis

Fahad Al-Ghimlas*, 1, Marie E Faughnan1, 2, Elizabeth Tullis1, 2
1 Department of Medicine, University of Toronto, Canada
2 St. Michael’s Hospital, Li Ka Shing Knowledge Institute, Canada

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© Al-Ghimlas et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Chest Unit, Department of Medicine, Amiri Hospital, P.O. Box 39810 Nuzha, Postal Code 73059, Kuwait; Tel: +(965) 22464725; Fax: +(965) 22435861; E-mail:



The frequency of metabolic alkalosis among adults with stable severe CF-lung disease is unknown.


Retrospective chart review.


Fourteen CF and 6 COPD (controls) patients were included. FEV1 was similar between the two groups. PaO2 was significantly higher in the COPD (mean ± 2 SD is 72.0 ± 6.8 mmHg,) than in the CF group (56.1 ± 4.1 mmHg). The frequency of metabolic alkalosis in CF patients (12/14, 86%) was significantly greater (p=0.04) than in the COPD group (2/6, 33%). Mixed respiratory acidosis and metabolic alkalosis was evident in 4 CF and 1 COPD patients. Primary metabolic alkalosis was observed in 8 CF and none of the COPD patients. One COPD patient had respiratory and metabolic alkalosis.


Metabolic alkalosis is more frequent in stable patients with CF lung disease than in COPD patients. This might be due to defective CFTR function with abnormal electrolyte transport within the kidney and/ or gastrointestinal tract.

Keywords: Cystic fibrosis, metabolic alkalosis..